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The EGF-R, also known as HER-1 or erbB-1 (EGF-R/HER-1/erbB-1), is a member of the human epithelial receptor tyrosine kinase
family. sEGF-R is considered to play a role in cardiac (patho)physiology. We aimed to investigate whether soluble EGF-R is
increased in congestive heart failure (CHF) patients and if related to disease severity. Soluble EGF-R, vitamin D, parathyroid
hormone (PTH) was studied, and being evaluated in relation to Ca2+, lipids, hsCRP, fibrinogen, serotonin, norepinepherine (NE). The study compared non-smoker, non-obese male CHF patients (n = 50) with age and gender-matched essential hypertension (HTN) patients (n = 20). Moreover, comparison with healthy control volunteers (n = 20) were employed. EGF-R/HER-1/erbB-1 was higher (P = 0.013) in 50 CHF male patients mean 12 ± 0.7 fmol/ml, than in 20 HTN, 9.25 ± 0.6 fmol/ml or in 20 controls, 6.25 ± 1 fmol/ml.
Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients.
This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin
D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Moreover, contributing to the complex
process of the inflammatory component of atherosclerosis in hypertensive patients that leads eventually to CHF. 相似文献
63.
The aim of the study was to examine whether a cognitive-behavioral self-help program was effective in improving depressed mood and anxiety in people with acquired deafness. Participants were 45 persons with acquired deafness, randomly allocated to the Cognitive-Behavioral Self-help (CBS) group or the Waiting List Control (WLC) group. Depression and anxiety scores were assessed at three measurement moments: at pretest, immediately after completion of the intervention (posttest), and again 2 months later (follow-up). To evaluate the effectiveness of the program, repeated measures analyses of covariance were performed. The results showed that depression and anxiety symptoms in the CBS group significantly improved after completion of the program, compared to the WLC group. There was no relapse from posttest to follow-up. It was concluded that a cognitive-behavioral self-help intervention could be an effective tool to reduce symptoms of depression and anxiety in people with acquired deafness. 相似文献
64.
Violent conduct by youths ranks among the types of inappropriate behavior generally originating in difficult family and social contexts. A proper understanding of the development of violent conduct must consider the situation taken as a whole. This article documents the results of a qualitative study which aimed to determine the psychosocial profiles and needs of youths with serious behavior problems and a family history of physical, psychological or sexual abuse. The results are based on the review of clinical files of 12 boys and 11 girls between the ages of 9 and 17, who were under child protection. The 23 files were analyzed to document the simultaneous evolution of behavior problems, abuse, family and school context, and the intervention of child protection services (reporting, evaluation, measures taken, foster care). The qualitative analysis followed the chronology and life history of each youth, resulting in the emergence of three generic profiles: the Undesirable, the Explosive, and the Delinquent. Each of the profiles is described and placed in perspective using the attachment, trauma and socialization theories respectively. The study concludes with proposals of distinct intervention models to be applied to these youths in the school environment. 相似文献
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Nadia Zavorotna 《Slavic & East European Information Resources》2013,14(2-3):192-198
In this article, the author discusses the creation of an electronic index of scholarly Slavic periodicals in the humanities, which will launch in early 2012. The aim of this project is to create a standard electronic reference tool in the field of Central, Eastern, and Southeastern European Studies, which will help professors, students, and researchers. The index contains important scholarly journals from Belarus, Bulgaria, Croatia, the Czech Republic, Macedonia, Poland, Serbia, Slovakia, Slovenia, and Ukraine. Indexing begins with 1994 issues and is ongoing. In the future, significant retrospective journals will be indexed in order to improve the tool's research capabilities. The index contains not only articles, but also all book reviews and information on conferences, workshops, organizations, and foundations. The index currently contains citations of over 125,000 articles from more than 143 Slavic journals in the humanities. The use of the Library of Congress transliteration scheme and subject headings will assist users to perform effective searches. 相似文献
66.
The Hartnett, Nelson, and Rinn 2004 study indicates that diagnostic confusion between ADD/ADHD and giftedness exists, and that research on medication practices is warranted. Mika disagrees, saying that there is no empirical evidence of misdiagnosis of gifted children as having ADD/ADHD. We disagree with Mika's logic, and describe evidence that suggests that such misdiagnosis does occur, with possible concurrent risks. 相似文献
67.
Nadia Farmakopoulou 《欧洲特需教育杂志》2013,28(1):49-59
This paper draws upon qualitative data from a study that examines inter-professional and inter-agency collaboration between education and social work authorities in assessing the special educational needs of pre-school children. It is argued that only by combining aspects of the three main models of inter-agency collaboration, namely the social exchange, power/resource dependency and political economy perspectives, is it possible to understand the complexity of inter-organizational relations and the reasons why collaboration into special educational needs continues to be limited in extent and poor in quality. It is shown how the motivation of inter-agency collaboration between education and social work authorities is simultaneously internal and voluntary (social exchange model) and external and involuntary, in terms of being imposed by a third party (political economy model). It is demonstrated how these two welfare agencies are engaging in some exchange and some power/resource dependency interactions. It is argued that it is difficult to assess the extent of interdependence (unilateral interdependence and reciprocal interdependence) in exchange relationships and, thus, whether there is symmetry and/or equality in these interactions. The internal and external factors that influence such interactions are briefly outlined in the final section. 相似文献
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Janet M. Shaw Nadia M. Hamad Tanner J. Coleman Marlene J. Egger Yvonne Hsu Robert Hitchcock 《Journal of sports sciences》2013,31(12):1176-1185
AbstractStrenuous physical activity has been linked to pelvic floor disorders in women. Using a novel wireless intra-vaginal pressure transducer, intra-abdominal pressure was measured during diverse activities in a laboratory. Fifty-seven women performed a prescribed protocol using the intra-vaginal pressure transducer. We calculated maximal, area under the curve and first moment of the area intra-abdominal pressure for each activity. Planned comparisons of pressure were made between levels of walking and cycling and between activities with reported high pressure in the literature. Findings indicate variability in intra-abdominal pressure amongst individuals doing the same activity, especially in activities that required regulation of effort. There were statistically significant differences in maximal pressure between levels of walking, cycling and high pressure activities. Results for area under the curve and first moment of the area were not always consistent with maximal pressure. Coughing had the highest maximal pressure, but had lower area under the curve and first moment of the area compared to most activities. Our data reflect novel findings of maximal, area under the curve and first moment of the area measures of intra-abdominal pressure, which may have clinical relevance for how physical activity relates to pelvic floor dysfunction. 相似文献
69.
The changes in the global information landscape, as epitomized by the reaction of governments to the 9/11 attacks, resulted in legislation, policy, and the formation of agencies that have affected many issues related to information and its use. This article examines the recent multiplicity of challenges that affect citizens' control and use of information. In the name of the war on terror, greater national security, and globalization trends, information laws, and policies often go further than is necessary and impact on the information rights of citizens. In this article, we advocate for bringing together what are at times disparate information issues under one label, namely, “information rights” (which include privacy, freedom of expression, access, etc.). Information rights are apprehended from a user-centered perspective (i.e., users as citizens, not just consumers). They cover many different aspects of the information life cycle and the roles and responsibilities of individuals and communities. Such an approach provides an alternative way of framing current information issues as they relate to national security policies and civil liberties in the broader sense. 相似文献
70.
ABSTRACTOne of the aims of the European Protocol in Preventive Conservation (EPICO) research programme was to implement a simple and flexible assessment method applicable to the majority of historic houses. We present results to verify statistical methods for the application in the assessment of heterogeneous in collections historic houses. For a collection with less than five hundred objects, a complete inventory by two people is possible, in order to collect information about the objects and their condition. A sample is representative when it has the same characteristics as the population studied. In the case of a very small population it is difficult to obtain representative results: here the sample should be almost equal to the total population. Therefore significant work must be done prior to assessment to properly identify the characteristics of the mother population. In the absence of sufficient representativeness, the results obtained from a sample cannot be generalized to the population being studied. 相似文献